C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2348828
The invention provides novel APM1 genomic sequences, polypeptides, antibodies, and polynucleotides including biallelic markers derived from the APM1 locus. Primers hybridizing to regions flanking these biallelic markers are also provided. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype.
L'invention concerne de nouvelles séquences génomiques, des polypeptides, des anticorps et des polynucléotides APM1 qui comprennent des marqueurs bialléliques dérivés du locus APM1. Elle porte également sur des amorces qui s'hybrident aux régions des flancs des marqueurs bialléliques, ainsi que sur des polynucléotides et des méthodes qui conviennent au génotypage d'un échantillon contenant un acide nucléique pour un ou plusieurs marqueurs bialléliques de l'invention. Elle concerne enfin des méthodes de détection d'une corrélation statistique entre un allèle de marqueur biallélique et un phénotype et/ou entre un haplotype de marqueur biallélique et un phénotype.
Bihain Bernard
Blumenfeld Marta
Bougueleret Lydie
Dufaure-Gare Isabelle
Genset S.a.
Serono Genetics Institute S.a.
Sim & Mcburney
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