C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/09 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2443146
A genomic DNA involved in rheumatoid arthritis, a method of diagnosing rheumatoid arthritis or a method of judging onset risk of rheumatoid arthritis, and a diagnostic kit for diagnosing rheumatoid arthritis or judging onset risk of rheumatoid arthritis, which genomic DNA comprises at least one of the following mutations in genomic DNA consisting of the base sequence of SEQ ID NO: 1: (1) substitution of thymine (t) for cytosine (c) at the position-1987; (2) substitution of guanine (g) for thymine (t) at the position-3664; and (3) substitution of cytosine (c) for adenine (a) at the position-3769.
L'invention concerne des ADN génomiques dérivés de l'ADN génomique représenté par SEQ iD NO:1, selon au moins une des variations suivantes; un procédé de diagnostic de la polyarthrite rhumatoïde humaine utilisant ces variations; un procédé d'estimation du risque d'apparition de celle-ci, et une trousse de diagnostic pour la détecter: (1) substitution de la cytosine (c) à la position-1987 en thymine (t); (2) substitution de la thymine (t) à la position-3664 en guanine (g); et (3) substitution de l'adénine (a) à la position-3769 en cytosine (c).
Komai Koichiro
Matsuura Nao
Shiozawa Shunichi
Yagi Hirofumi
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Shiozawa Shunichi
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