Genomic profiling of regulatory factor binding sites

Details Genomic profiling of regulatory factor binding sites Genomic profiling of regulatory factor binding sites

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2519674

A method is provided for profiling regulatory factor binding sites. A complete gene is located on genome for mapping gene regulatory regions. The genomic position of the most up-stream transcription start sites (TSS) of gene is identified. Genomic sequences of gene regulatory regions are defined and retrieved based on the identified TSS. DNA sequence information of each retrieved gene regulatory region is screened for identifying putative regulatory factor binding sites. The putative regulatory factor binding sites and their genomic occurrences are profiled.

L'invention concerne un procédé de profilage de sites de liaison de facteurs régulateurs. Un gène complet est situé sur un génome aux fins de cartographie des régions régulatrices de gènes. La position génomique du site de départ de la transcription le plus en amont (TSS) d'un gène est identifiée. Des séquences génomiques de régions régulatrices de gènes sont définies et récupérées en fonction du TSS identifié. Des informations de séquences d'ADN de chaque région régulatrice de gènes récupérée sont balayées aux fins d'identification de sites de liaison de facteurs régulateurs putatifs. Ceux-ci et les occurrences génomiques de ceux-ci sont profilés.

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