C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) A61K 31/165 (2006.01) A61K 31/7068 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12Q 1/04 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2478592
A method of identifying epigenetically silenced genes, e.g., methylation silenced genes,in cancer cells is provided. In addition, methods of identifying a cancer by detecting epigenetic silencing of gene expression are provided, as are methods of treating a subject having such a cancer, for example, a colorectal cancer and/or gastric cancer. Reagents for practicing such methods also are provided.
Cette invention concerne une méthode d'identification de gènes rendus épigénétiquement silencieux, tels que des gènes rendus silencieux par méthylation, dans des cellules cancéreuses. Cette invention concerne en outre des méthodes d'identification d'un cancer par la détection du silençage épigénétique de l'expression génique, ainsi que des méthodes de traitement d'un sujet atteint d'un cancer, tel qu'un cancer colorectal et/ou un cancer gastrique. Cette invention porte enfin sur des réactifs permettant de mettre en oeuvre ces méthodes.
Baylin Stephen B.
Herman James G.
Sidransky David
Suzuki Hiromu
Osler Hoskin & Harcourt Llp
The Johns Hopkins University School Of Medicine
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