Genomic screen for epigenetically silenced tumor suppressor...

Details Genomic screen for epigenetically silenced tumor suppressor... Genomic screen for epigenetically silenced tumor suppressor...

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 9/127 (2006.01) A61K 31/165 (2006.01) A61K 31/7068 (2006.01) A61K 35/76 (2006.01) A61K 38/00 (2006.01) A61K 45/00 (2006.01) A61K 47/24 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12N 1/00 (2006.01) C12N 15/09 (2006.01) C12Q 1/04 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 37/00 (2006.01)

Patent

CA 2478510

Methods of genomic screening to identify epigenetically silenced genes, including epigenetically silenced tumor suppressor genes are provided. Also provided are methods of detecting a cancer, for example, an esophageal squamous cell carcinoma or a head and neck squamous cell carcinoma, as are methods of treating a subject having such a cancer.

Cette invention porte sur des méthodes de dépistage génomique permettant d'identifier des gènes rendus épigénétiquement silencieux, y compris des gènes suppresseurs de tumeur rendus épigénétiquement silencieux. Cette invention porte également sur des méthodes de dépistage d'un cancer, tel qu'un carcinome squameux de l'oesophage ou un carcinome squameux de la tête et du cou, ainsi que sur des méthodes de traitement d'un sujet atteint d'un tel cancer.

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