Genotyping human udp-glucuronosyltransferase 2b4 (ugt2b4),...

Details Genotyping human udp-glucuronosyltransferase 2b4 (ugt2b4),... Genotyping human udp-glucuronosyltransferase 2b4 (ugt2b4),...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2334957

Genetic polymorphisms are identified in the human UGT2B4, UGT2B7 and UGT2B15 genes that alter UGT2B activity. Nucleic acids comprising the polymorphic sequences are used to screen patients for altered metabolism for UGT2B substrates, potential drug-drug interactions, and adverse/side effects, as well as diseases that result from environmental or occupational exposure to toxins. The nucleic acids are used to establish animal, cell and in vitro models for drug metabolism.

Des polymorphismes génétiques ont été identifiés dans les gènes humains de UGT2B4, UGT2B7 et UGT2B15, qui modifient l'activité de UGT2B. Selon l'invention on utilise des acides nucléiques comprenant les séquences polymorphiques pour cribler des patients, à la recherche du métabolisme modifié de substrats UGT2B, d'interactions potentielles médicamenteuses et d'effets secondaires, de même qu'à la recherche de maladies induites par une exposition ambiante ou professionnelle aux toxines. On utilise les acides nucléiques pour établir des modèles animaux, cellulaires et in vitro, du métabolisme des médicaments.

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