C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/10 (2006.01) A61K 31/404 (2006.01) A61P 3/10 (2006.01) A61P 35/00 (2006.01) C07D 209/34 (2006.01) C07D 403/14 (2006.01)
Patent
CA 2534509
The present invention relates to certain sulfonamido-substituted geometrically restricted indolinones of the formula (I): wherein R1 - R12 and X are variables defined herein. The sulfonamido-substituted geometrically restricted indolinones of the preferred embodiments of the present invention modulate the activity of protein kinases ("PKs"). The compounds of this invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical compositions comprising these compounds, methods of treating diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
L'invention concerne certaines indolinones à substitution sulfonamido géométriquement limitées, représentées par la formule (I), dans laquelle R¿1? - R¿12 ?et X représentent des variables définies. Dans les formes de réalisation préférées, les indolinones modulent l'activité de protéines kinases (<= PK >=). Cescomposés sont donc utiles dans le traitement de troubles liés à une activité anormale des PK. L'invention concerne des compositions pharmaceutiques comprenant ces composés, des méthodes de traitement de maladies à l'aide de ces compositions ainsi que des procédés de préparation de celles-ci.
Chen Wei Chung
Cho Tang Peng
Cui Jingrong
Zhang Fang-Jie
Smart & Biggar
Sugen Inc.
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