Geometrically restricted 2-indolinone derivatives as...

Details Geometrically restricted 2-indolinone derivatives as... Geometrically restricted 2-indolinone derivatives as...

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/34 (2006.01) A61K 31/35 (2006.01) A61K 31/36 (2006.01) A61K 31/38 (2006.01) A61K 31/385 (2006.01) A61K 31/39 (2006.01) A61K 31/40 (2006.01) A61K 31/404 (2006.01) A61K 31/405 (2006.01) A61K 31/41 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/425 (2006.01) A61K 31/435 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/50 (2006.01) A61K 31/505 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61P 3/10 (2006.01

Patent

CA 2342222

The present invention relates to novel geometrically restricted 2-indolinones and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

La présente invention concerne des dérivés de 2-indolinone à géométrie limitée ainsi que des sels pharmaceutiquement acceptables de ces dérivés qui modulent l'activité de la protéine kinase et qui devraient être utiles pour la prévention et le traitement de troubles cellulaires liées à la protéine kinase, le cancer notamment.

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