C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07H 21/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) C12N 15/28 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01) C12P 21/06 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2162150
The present invention relates to somatic mutations in the Multiple Tumor Suppressor (MTS) gene in human cancers and their use in the diagnosis and prognosis of human cancer. The invention further relates to germ line mutations in the MTS gene and their use in the diagnosis of predisposition to melanoma, leukemia, astrocytoma, glioblastoma, lymphoma, glioma, Hodgkin's lymphoma, CLL, and cancers of the pancreas, breast, thyroid, ovary, uterus, testis, kidney, stomach and rectum. The invention also relates to the therapy of human cancers which have a mutation in the MTS gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy.
L'invention concerne des mutations somatiques du gène MTS (suppresseur de tumeurs multiples) dans les cancers de l'homme, ainsi que leur utilisation pour le diagnostic et le pronostic de ces cancers. L'invention concerne aussi des mutations de lignées germinales dans le gène MTS et leur utilisation dans le diagnostic de prédisposition au mélanome, à la leucémie, à l'astrocytome, au glioblastome, au lymphome, au gliome, à la maladie de Hodgkin, à la leucémie lymphoïde chronique et aux cancers du pancréas, du sein, de la thyroïde, de l'ovaire, de l'utérus, du testicule, du rein, de l'estomac et du rectum. Elle concerne aussi la thérapie des cancers de l'homme qui présentent une mutation du gène MTS, y compris la thérapie génique, la protéinothérapie substitutive et les mimétiques de protéines. Cette invention concerne enfin le tri de substances de thérapie anti-cancéreuse.
Cannon-Albright Lisa A.
Kamb Alexander
Skolnick Mark H.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Myriad Genetics Inc.
University Of Utah Research Foundation
LandOfFree
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