C - Chemistry – Metallurgy – 40 – B
Patent
C - Chemistry, Metallurgy
40
B
C40B 40/06 (2006.01) A61K 31/513 (2006.01) A61K 31/519 (2006.01) C12Q 1/68 (2006.01) C40B 30/04 (2006.01)
Patent
CA 2684945
The invention provides compositions and methods for determining the likelihood of successful treatment with pyrimidine based antimetabolites and platinum-based alkylating agents. The methods comprise determining the identity of one or more genomic polymorphism present in a predetermined region of a gene of interest and correlating the polymorphism to the predictive response and treatment options. Patients identified as responsive are then treated with the appropriate therapy.
La présente invention concerne des compositions et des procédés permettant de déterminer la probabilité de succès d'un traitement par antimétabolites à base de pyrimidine et d'agents alkylants à base de platine. Les procédés comprennent de déterminer l'identité d'un ou plusieurs polymorphismes génomiques présents dans une région prédéterminée d'un gène d'intérêt et de corréler le polymorphisme à la réponse prédictive et aux options thérapeutiques. Les patients identifiés comme répondants reçoivent alors le traitement.
Smart & Biggar
University Of Southern California
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