Gfr.alpha.1-ret specific agonists and methods therefor

Details Gfr.alpha.1-ret specific agonists and methods therefor Gfr.alpha.1-ret specific agonists and methods therefor

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 31/7088 (2006.01) A61K 38/18 (2006.01) C07K 14/475 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2396039

Chimeric GDNF family ligands which activate a GFR.alpha./RET are disclosed. Included are chimeras which activate GFR.alpha.1/RET but do not activate GFR.alpha.2-RET or GFR.alpha.3-RET. The chimeras are useful in providing trophic support to a mammalian cell or in producing differentiation of a mammalian cell, or both, particularly when the cell is in a patient suffering from various diseases, in particular Parkinson's Disease.

L'invention concerne des ligands chimères de la famille GDNF activant un GFR.alpha./RET. Elle englobe des chimères activant GRF.alpha.1/RET mais n'activant pas GFR.alpha.2-RET ou GRF.alpha.3-RET. Ces chimères sont utiles pour apporter un support trophique à une cellule mammifère ou pour produire une différenciation de cellules mammifères, ou les deux, en particulier quand la cellule appartient à un patient atteint de différentes maladies, en particulier, la maladie de Parkinson.

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