Ghrelin binding nucleic acids

Details Ghrelin binding nucleic acids Ghrelin binding nucleic acids

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/713 (2006.01) C12Q 1/68 (2006.01) A61P 1/00 (2006.01) A61P 3/04 (2006.01)

Patent

CA 2605377

The present invention is related to a nucleic acid, preferably binding to ghrelin, whereby the nucleic acid comprises a first stretch Box A, and a second stretch Box B, whereby the first stretch Box A comprises about 25 consecutive nucleotides, the second stretch Box B comprises about six to eight consecutive nucleotides, whereby a 3'-terminal stretch of nucleotides of the first stretch Box A hybridises with the second stretch Box B, whereby upon hybridisation a first double-stranded structure is formed, whereby such first double-stranded structure comprises a bulge.

La présente invention se rapporte à un acide nucléique se liant de préférence à la ghréline, ledit acide nucléique comportant une première boîte A de suite nucléotidique et une seconde boite B de suite nucléotidique, ladite première boîte A de suite nucléotidique comprenant environ 25 nucléotides consécutifs, la seconde boîte B de suite nucléotidique comportant environ 6 à 8 nucléotides consécutifs, une suite 3'-terminale de nucléotides de la première boîte A de suite nucléotidique s'hybridant avec la seconde boîte B de suite nucléotidique, l'hybridation permettant la formation d'une première structure à double brin et cette première structure à double brin comprenant un renflement.

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