Ghsr ligand polypeptides and dnas thereof

Details Ghsr ligand polypeptides and dnas thereof Ghsr ligand polypeptides and dnas thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/72 (2006.01) C07K 16/18 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2389574

Polypeptides characterized by containing an amino acid sequence identical or substantially identical with the amino acid sequence represented by SEQ ID NO:1 which are useful in developing drugs such as GH secretion controlling agents, or amides, esters or salts thereof; DNAs encoding these polypeptides, or amides, esters or salts thereof; a method/kit for screening a compound capable of changing the binding properties of these polypeptides to GHSR, etc.

L'invention porte sur des polypeptides caractérisés en ce qu'ils contiennent une séquence d'acides aminés identique ou quasi identique avec celle représentée par SEQ ID NO:1 et s'avérant utiles pour l'élaboration de médicaments tels que des agents régulateurs des sécrétions de GH, ou leurs amides, esters ou sels. L'invention porte également sur les ADN codant pour ces polypeptides ou leurs amides, esters ou sels, et sur une méthode/trousse de criblage d'un composé pouvant modifier les caractéristiques de fixation de ces polypeptides au GHSR, etc.

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