Gip analog and hybrid polypeptides with selectable properties

Details Gip analog and hybrid polypeptides with selectable properties Gip analog and hybrid polypeptides with selectable properties

C - Chemistry, Metallurgy

07

K

C07K 14/575 (2006.01)

Patent

CA 2597649

The present invention relates generally to novel GIP analogs and GIP hybrid polypeptides with selectable properties, useful as agents for the treatment and prevention of metabolic diseases and disorders, for example those which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, positive inotropic effects, reduction of catabolic effects, slowing of gastric emptying. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, critical care, insulin-resistance, obesity, and diabetes mellitus of any kind, including type 1, type 2, and gestational diabetes.

La présente invention concerne d'une façon générale de nouveaux analogues de GIP et des polypeptides hybrides de GIP aux propriétés sélectionnables, convenant comme agents pour le traitement et la prévention d'affections et de troubles du métabolisme, par exemple ceux qui peuvent être améliorés par une régulation du niveau de glucose dans le plasma, des niveaux d'insuline, et/ou de la sécrétion d'insuline, les effets inotropes positifs, la réduction des effets du catabolisme, et le ralentissement de la vidange gastrique. Les troubles et états concernés sont notamment l'hypertension, la dyslipidémie, les maladies cardiovasculaires, les troubles de l'alimentation, les soins intensifs, la résistance à l'insuline, l'obésité, et le diabète de toute sorte, y-compris de type 1 et de type 2, et le diabète gestationnel.

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