C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2468851
The present invention provides isolated GPBP-interacting 90 and 130 kDa polypeptides, and portions thereof (GIP90/130 polypeptides), antibodies to the GIP90/130 polypeptides, and pharmaceutical compositions thereof. The present invention also provides isolated GIP90/130 nucleic acid sequences, expression vectors comprising the nucleic acid sequences, and host cells transfected with the expression vectors. The invention further provides methods for detecting the GIP90/130 polypeptides or nucleic acid sequences, methods for inhibiting interactions between GPBP and GIP90/130 polypeptides, betwee pol k76 and GIP90/130 polypeptides or aggregation of GIP90/130 polypeptides, and methods for treating patients with autoimmune disorders or cancer.
L'invention concerne des polypeptides isolés kDa 90 et 130 d'interaction GPBP, des parties de ceux-ci (polypeptides GIP90/130), des anticorps aux polypeptides GIP90/130, ainsi que des compositions pharmaceutiques associées. Cette invention concerne aussi des séquences d'acide nucléique isolées GIP90/130, des vecteurs d'expression contenant ces séquences d'acide nucléique, et des cellules hôtes transfectées par ces vecteurs d'expression. La présente invention porte également sur des procédés pour détecter les polypeptides GIP90/130 ou les séquences d'acide nucléique GIP90/130, sur des procédés pour inhiber des interactions entre les polypeptides GPBP et GIP90/130, entre les polypeptides pol k76 et GIP90/130 ou l'agrégation de polypeptides GIP90/130, et sur des méthodes pour traiter des patients atteints de maladies auto-immunes ou d'un cancer.
Revert-Ros Francisco
Saus Juan
Fibrostatin Sociedad Limitada
Revert-Ros Francisco
Saus Juan
Smart & Biggar
LandOfFree
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