Gitr binding molecules and uses therefor

Details Gitr binding molecules and uses therefor Gitr binding molecules and uses therefor

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/12 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2602777

The present invention provides binding molecules that specifically bind to GITR, e.g., human GITR (hGITR), on T cells and dendritic cells. Binding molecules of the invention are characterized by binding to hGITR with high affinity, in the presence of a stimulating agent, e.g., CD3, are agonistic, and abrogate the suppression of Teff cells by Treg cells. Various aspects of the invention relate to binding molecules, and pharmaceutical compositions thereof, as well as nucleic acids, recombinant expression vectors and host cells for making such binding molecules. Methods of using a binding molecule of the invention to detect human GITR or to modulate human GITR activity, either in vitro or in vivo, are also encompassed by the invention.

La présente invention porte sur des molécules de liaison qui se lient spécifiquement à GITR, tel que GITR humain (hGITR), sur des lymphocytes T et des cellules dendritiques. Les molécules de liaison de l'invention sont caractérisées en ce qu'elle se lient à hGITR avec une haute affinité, en présence d'un agent stimulant, tel que CD3, sont des agonistes et annulent la suppression des cellules Teff par les cellules Treg. Divers aspects de l'invention portent sur des molécules de liaison et sur leurs compositions pharmaceutiques, ainsi que sur des acides nucléiques, des vecteurs d'expression de recombinaison et des cellules hôtes permettant de fabriquer ces molécules de liaison. L'invention porte, en outre, sur des procédés d'utilisation d'une molécule de liaison afin de détecter GITR humain ou de moduler l'activité de GITR humain, in vitro ou in vivo.

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