C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/19 (2006.01) C12N 5/0783 (2010.01) C12N 15/113 (2010.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) A61K 39/39 (2006.01) A61K 39/395 (2006.01) C07K 14/52 (2006.01) C07K 14/715 (2006.01) C07K 16/24 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2525717
The present invention provides novel isolated and purified polynucleotides and polypeptides related to a novel ligand for glucocorticoidinduced TNF receptor (GITR). The invention also provides antibodies to the GITR ligand (GITRL). The present invention also is directed to novel methods for diagnosing, prognosing, monitoring the progress of, and treating disorders arising from disregulation of the immune system (e.g., autoimmune disorders, inflammatory diseases, and transplant rejection, and cancers and infectious diseases) using GITRL and/or modulators of GITRL. The present invention is further directed to novel therapeutics and therapeutic targets and to methods of screening and assessing test compounds for the intervention (treatment) and prevention of said disorders arising from disregulation of the immune system, as related to GITRL and GITR.
La présente invention concerne de nouveaux polynucléotides et polypeptides isolés et purifiés liés à un nouveau ligand du récepteur du TNF induit par glucocorticoïde (GITR). L'invention concerne également des anticorps contre le ligand du GITR (GITRL). La présente invention concerne également de nouvelles méthodes de diagnostic, de pronostic, de suivi de l'évolution et de traitement de troubles dus à un dérèglement du système immun (par exemple des troubles auto-immuns, des maladies inflammatoires, des rejets de greffe ainsi que des cancers et des maladies infectieuses) utilisant le GITRL et/ou de modulateurs du GITRL. La présente invention concerne également de nouvelles thérapeutiques et de nouveaux agents thérapeutiques ainsi que des procédés de criblage et d'évaluation de composés d'essai pour l'intervention (traitement) et la prévention desdits troubles provenant d'un dérèglement du système immun, liés au GITRL et au GITR.
Byrne Michael Chapman
Carreno Beatriz M.
Collins Mary
Mchugh Rebecca Suzanne
Reddy Padmalatha S.
The Government Of The United States Of America As Represented By
Torys Llp
Wyeth
LandOfFree
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