Glia activating factor and its production

Details Glia activating factor and its production Glia activating factor and its production

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) C07K 14/475 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2061148

Disclosed are (1) a novel glia activating factor which has glial cell growth promoting activity; (2) a glia activating factor containing a polypeptide represented by the following amino acid sequence: Leu Asp His Leu Lys Gly Ile Leu Arg Arg Arg Gln Leu Tyr Cys Arg Thr Gly Phe His Leu Glu Ile Phe Pro Asn Gly Thr Ile Gln Gly Thr Arg Lys Asp His Ser Arg Phe Gly Ile Leu Glu Phe Ile Ser Ile Ala Val Gly Leu Val Ser Ile Arg Gly Val Asp Ser Gly Leu Tyr Leu Gly Met Asn Glu Lys Gly Glu Leu Tyr Gly Ser Glu Lys Leu Thr Gln Glu Cys Val Phe Arg Glu Gln Phe Glu Glu Asn Trp Tyr Asn Thr Tyr Ser Ser Asn Leu Tyr Lys His Val Asp Thr Gly Arg Arg Tyr Tyr Val Ala Leu Asn Lys Asp Gly Thr Pro Arg Glu Gly Thr Arg Thr Lys Arg His Gln Lys Phe Thr His Phe Leu Pro Arg Pro VaZ Asp Pro Asp ; or a mutein thereof having activity of the factor: (3) a DNA containing a following polynucleotide coding for a glia activating factor: TTG GATCATTTAA AGGGGATTCT CAGGCGGAGG CAGCTATACT GCAGGACTGG ATTTCACTTA GAAATCTTCC CCAATGGTAC TATCCAGGGA ACCAGGAAAG ACCACAGCCG ATTTGGCATT CTGGAATTTA TCAGTATAGC AGTGGGCCTG GTCAGCATTC GAGGCGTGGA CAGTGGACTC TACCTCGGGA TGAATGAGAA GGGGGAGCTG TATGGATCAG AAAAACTAAC CCAAGAGTGT GTATTCAGAG AACAGTTCGA AGAAAACTGG TATAATACGT ACTCGTCAAA CCTATATAAG CACGTGGACA CTGGAAGGCG ATACTATGTT GCATTAAATA AAGATGGGAC CCCGAGAGAA GGGACTAGGA CTAAACGGCA CCAGAAATTC ACACATTTTT TACCTAGACC AGTGGACCCC GAC. (4) a host transformed with a vector containing the DNA described in (3); and (5) a method for producing the above glia activating factor which comprises cultivating the transformant described in (4) in a medium, accumulating the glia activating factor in a culture broth, and collecting the resulting glia activating factor.

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