Glial cell line-derived neurotrophic factor receptors

Details Glial cell line-derived neurotrophic factor receptors Glial cell line-derived neurotrophic factor receptors

C - Chemistry, Metallurgy

07

K

C07K 14/71 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2237641

Receptors for Glial Cell Line-Derived Neurotrophic Factor (GDNF), their cellular expression, isolation, and biochemical characterization are disclosed. C-RET is disclosed as one receptor for GDNF; additional novel receptors are also disclosed. The preparation of monoclonal antibodies directed against GDNF is also disclosed.

L'invention concerne des récepteurs du factor neurotrophique dérivé de lignées de cellules gliales (GDNF), leur expression cellulaire, leur isolement et leur caractérisation biochimique. Le récepteur c-RET est présenté comme un récepteur de GDNF. Des récepteurs nouveaux supplémentaires sont décrits ainsi que la préparation d'anticorps monoclonaux dirigés contre GDNF.

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