C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A61K 9/00 (2006.01) A61K 35/30 (2006.01) A61K 38/18 (2006.01) C07K 1/113 (2006.01) C07K 14/475 (2006.01) C07K 14/48 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2119463
A novel neurotrophic factor referred to as a glial cell line-derived neurotrophic factor (GDNF) has been identified and isolated from serum free growth conditioned medium of B49 glioblastoma cells. Rat and human genes encoding GDNF have been cloned and sequenced. A gene encoding GDNF has been subcloned into a vector, and the vector has been used to transform a host cell in order to produce biologically active GDNF in a recombinant DNA process.
Bektesh Susan
Collins Franklin D.
Doherty Daniel H.
Lile Jack
Lin Leu-Fen H.
Amgen Inc.
Smart & Biggar
Synergen Inc.
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