C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) C07K 16/18 (2006.01) C07K 16/22 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2191085
Disclosed is the characterization and purification of DNA encoding a numerous polypeptides useful for the stimulation of glial cell (particularly, Schwann cell) mitogenesis and treating glial cell tumors. Also disclosed are DNA sequences encoding novel polypeptides which may have use in stimulating glial cell mitogenesis and treating glial cell tumors. Methods for the synthesis, purification and testing of both known and novel polypeptides for their use as both therapeutic and diagnostic aids in the treatment of diseases involving glial cells are also provided. Methods are also provided for the use of these polypeptides for the preparation of antibody probes useful for both diagnostic and therapeutic use in diseases involving glial cells.
La présente invention concerne la caractérisation et la purification d'un ADN codant plusieurs polypeptides permettant de stimuler la mitogénèse des cellules gliales (notamment les cellules de Schwann) et de traiter des tumeurs de cellules gliales. L'invention concerne également des séquences d'ADN codant des polypeptides nouvellement découverts et susceptibles de permettre de stimuler la mitogénèse des cellules gliales et de traiter des tumeurs de cellules gliales. L'invention concerne en outre des procédés de synthèse, de purification et de test de polypeptides connus ou récemment découverts en vue de leur utilisation comme moyens thérapeutiques et aides au diagnostic pour le traitement d'affections impliquant les cellules gliales. L'invention concerne enfin des procédés d'utilisation de ces polypeptides en vue de la préparation de sondes d'anticorps utilisables à des fins thérapeutiques et de diagnostic impliquant les cellules gliales.
Chen Maio Su
Goodearl Andrew David
Hiles Ian
Marchionni Mark
Minghetti Luisa
Cambridge Neuroscience
Cenes Pharmaceuticals Inc.
Ludwig Institute For Cancer Research
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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