Glms riboswitches, structure-based compound design with glms...

Details Glms riboswitches, structure-based compound design with glms... Glms riboswitches, structure-based compound design with glms...

C - Chemistry, Metallurgy

07

H

C07H 15/02 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) A61P 31/04 (2006.01) C07H 11/04 (2006.01) C07H 13/00 (2006.01) C07H 15/12 (2006.01) C12N 15/00 (2006.01) C12N 15/63 (2006.01) C12Q 1/34 (2006.01) C12Q 1/68 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2662506

The glmS riboswitch is a target for antibiotics and other small molecule therapies. Compounds can be used to stimulate, active, inhibit and/or inactivate the glmS riboswitch. The atomic structures of the glmS riboswitch can be used to design new compounds to stimulate, active, inhibit and/or inactivate riboswitches.

La présente invention concerne un ribozyme-commutateur glmS qui est la cible d'antibiotiques et d'autres traitements utilisant des petites molécules. L'invention concerne des composés qui peuvent être utilisés pour stimuler, activer, inhiber et/ou inactiver le ribozyme-commutateur glmS. La structure atomique du ribozyme-commutateur glmS peut être utilisée pour concevoir de nouveaux composés permettant de stimuler, activer, inhiber et/ou inactiver les ribozymes-commutateurs.

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