Glp-1 analogs useful for diabetes treatment

Details Glp-1 analogs useful for diabetes treatment Glp-1 analogs useful for diabetes treatment

C - Chemistry, Metallurgy

07

K

C07K 14/605 (2006.01) A61K 38/26 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2073856

The invention provides effective analogs of the active GLP-1 peptides, 7-34, 7- 35, 7-36, and 7-37, which have improved characteristics for treatment of diabetes Type II. These analogs have amino acid substitutions at positions 7-10 and/or are trun- cated at the C-terminus and/or contain various other amino acid substitutions in the basin peptide. The analogs may either have an enhanced capacity to stimulate insulin production as compared to glucagon or may exhibit enhanced stability in plasma as compared to GLP-1 (7-37) or both. Either of these properties will enhance the potency of the analog as a therapeutic. Analogs having D-amino acid substitutions in the 7 and 8 positions and/or N-alkylated or N-acylated amino acids in the 7 position are particularly resistant to degradation in vivo.

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