Glp-1 and methods for treating diabetes

Details Glp-1 and methods for treating diabetes Glp-1 and methods for treating diabetes

C - Chemistry, Metallurgy

07

K

C07K 14/575 (2006.01) A61K 38/22 (2006.01) A61K 38/26 (2006.01) A61K 38/28 (2006.01) A61K 38/31 (2006.01) A61K 47/48 (2006.01) A61P 3/10 (2006.01) C07K 14/605 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2490564

The present invention relates to use of GLP-1 or a related molecule having GLP- effect for the manufacture of a medicament for preventing or treating diabetes in a mammal. The amount and timing of administration of said medicament are subsequently reduced to produce a "drug holiday". Practice of the invention achieves effective therapy without continuous drug exposure and without continuous presence of therapeutic levels of the drug. The invention also discloses a method of treating diabetes and related disorders in a mammal by administering glucagon like peptide (GLP-1) or a related molecule having GLP-1 like effect and thereby providing a therapeutically effective amount of endogenous insulin.

La présente invention concerne l'utilisation du GLP-1 ou d'une molécule associée ayant un effet GLP pour l'élaboration d'un médicament servant à prévenir ou à traiter le diabète chez un mammifère. La dose et la durée de l'administration dudit médicament sont par la suite réduits pour produire une <= fenêtre thérapeutique >=.L'invention permet d'obtenir une thérapie efficace sans exposition continue à des médicaments et sans présence continue de doses thérapeutiques du médicament. L'invention concerne également une méthodes de traitement du diabète et de troubles associés chez un mammifère consistant à administrer un glucagon-like peptide (GLP-1) ou une molécule associée ayant un effet analogue au GLP-1 pour ainsi fournir une dose thérapeutique d'insuline endogène.

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