Glp-1 pegylated compounds

Details Glp-1 pegylated compounds Glp-1 pegylated compounds

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61P 3/10 (2006.01) C07K 14/605 (2006.01)

Patent

CA 2608311

The invention provides GLP-1 compounds coupled to two polyethylene glycol molecule or derivative thereof, resulting in a biologically active peptide with an extended half-life and a slower clearance when compared to that of unPEGylated peptide. These PEGylated GLP-1 compounds and compositions are useful in treating conditions or disorders benefited by lowering blood glucose, decreasing food intake, decreasing gastric or intestinal emptying, increasing beta (~) cell population, or decreasing gastric or intestinal motility.

L'invention concerne des composés GLP-1 couplés à deux molécules de polyéthylèneglycol ou des dérivés de celles-ci, ces composés permettant d'obtenir un peptide biologiquement actif présentant une demi-vie prolongée et une clairance plus lente comparativement à celles d'un peptide non pégylé. Ces composés GLP-1 pégylés et ces compositions sont utiles pour traiter des états ou des troubles pour lesquels une réduction de la glycémie, de la ration alimentaire et de la vidange gastrique ou intestinale et une augmentation de la population de cellules bêta (ß) ou une réduction de la motilité gastrique ou intestinale sont bénéfiques.

Affiliated with

Also associated with

Rating

Glp-1 pegylated compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Glp-1 pegylated compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Glp-1 pegylated compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1630492