Glucagon analogs exhibiting physiological solubility and...

Details Glucagon analogs exhibiting physiological solubility and... Glucagon analogs exhibiting physiological solubility and...

A - Human Necessities

61

K

A61K 38/26 (2006.01)

Patent

CA 2628241

Modified glucagon peptides are disclosed having improved solubility and stability, wherein the native glucagon peptide has been modified by pegylation, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO: 19, SEQ ID NO: 20, SEQ ID NO: 21, or both.

L'invention concerne des peptides glucagon modifiés à solubilité et à stabilité améliorées. Le peptide glucagon natif de l'invention est modifié par pégylation et/ou par addition d'un peptide à extrémité carboxylique sélectionné dans le groupe comprenant les séquences suivantes : SEQ ID NO: 19, SEQ ID NO: 20, SEQ ID NO: 21.

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