Glucagon antagonists/inverse agonists

Details Glucagon antagonists/inverse agonists Glucagon antagonists/inverse agonists

C - Chemistry, Metallurgy

07

C

C07C 237/32 (2006.01) A61K 31/15 (2006.01) A61K 31/165 (2006.01) A61K 31/17 (2006.01) A61K 31/33 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) C07C 237/36 (2006.01) C07C 237/42 (2006.01) C07C 243/24 (2006.01) C07C 243/38 (2006.01) C07C 271/40 (2006.01) C07C 271/56 (2006.01) C07C 271/58 (2006.01) C07C 275/24 (2006.01) C07C 275/26 (2006.01) C07C 275/28 (2006.01) C07C 275/30 (2006.01) C07C 275/34 (2006.01) C07C 275/36 (2006.01) C07C 275/38 (2006.01) C07C 275/42 (2006.01) C07C 275/60 (2006.01) C07C 275/62 (

Patent

CA 2373892

A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any glucagon-mediated conditions and diseases such as hyperglycemia, Type 1 diabetes, Type 2 diabetes and obesity.

L'invention concerne une nouvelle classe de composés qui s'opposent à l'action de l'hormone de glucagon sur le récepteur de glucagon. Dans la mesure où ils produisent des effets antagonistes sur le récepteur de glucagon, les composés de cette invention peuvent convenir pour traiter et/ou prévenir tout état ou maladie ayant pour origine le glucagon, par exemple l'hyperglycémie, le diabète insulino-dépendant, le diabète non insulino-dépendant, et l'obésité.

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