Glucagon antagonists/inverse agonists

Details Glucagon antagonists/inverse agonists Glucagon antagonists/inverse agonists

C - Chemistry, Metallurgy

07

C

C07C 275/24 (2006.01) A61K 31/166 (2006.01) A61K 31/167 (2006.01) A61K 31/17 (2006.01) A61K 31/4035 (2006.01) A61K 31/429 (2006.01) A61K 31/44 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) C07C 237/20 (2006.01) C07C 237/32 (2006.01) C07C 237/42 (2006.01) C07C 275/28 (2006.01) C07C 275/30 (2006.01) C07C 275/34 (2006.01) C07C 275/42 (2006.01) C07C 317/42 (2006.01) C07C 323/44 (2006.01) C07D 209/08 (2006.01) C07D 209/42 (2006.01) C07D 209/48 (2006.01) C07D 213/36 (2006.01) C07D 213/40 (2006.01) C07D 213/75

Patent

CA 2411552

A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any diseases and disorders, wherein a glucagon antagonistic action is beneficial, such as hyperglycemia, Type 1 diabetes, Type 2 diabetes, disorders of the lipid metabolism and obesity.

L'invention concerne une nouvelle classe de composés servant à antagoniser l'action de l'hormone appelée glucagon, sur le récepteur du glucagon. Etant donné leur effet antagoniste du récepteur du glucagon, ces composés sont appropriés au traitement et/ou à la prévention de tout trouble ou pathologie dans lequel une action antagoniste du glucagon est souhaitable, tel que l'hyperglycémie, les diabètes de type 1 et 2, des troubles du métabolisme lipidique, et l'obésité.

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