Glucagon-like peptide-1 analogs

Details Glucagon-like peptide-1 analogs Glucagon-like peptide-1 analogs

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A61K 38/16 (2006.01) A61K 38/26 (2006.01) C07K 14/605 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2458371

Disclosed are glucagon-like peptide-1 (GLP-1) compounds with modifications at one or more of the following positions: 7, 8, 12, 16, 18, 19, 20, 22, 25, 27, 30, 33, and 37. Methods of treating a subject in need of GLP-1 receptor stimulation using these GLP-1 compounds are also disclosed.

L'invention concerne des composés de GLP-1 (glucagon-like peptide-1) présentant des modifications sur une ou plusieurs des positions suivantes: 7, 8, 12, 16, 18, 19, 20, 22, 25, 27, 30, 33, et 37. L'invention concerne en outre des méthodes permettant de traiter un sujet nécessitant une stimulation du récepteur de GLP-1 par administration de ces composés de GLP-1.

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