Glucagon-like peptide-1 analogs with long duration of action

Details Glucagon-like peptide-1 analogs with long duration of action Glucagon-like peptide-1 analogs with long duration of action

C - Chemistry, Metallurgy

07

K

C07K 14/605 (2006.01) A61K 38/26 (2006.01) A61P 3/08 (2006.01) A61P 3/10 (2006.01) A61P 5/50 (2006.01)

Patent

CA 2552526

Novel GLP-1 analogs having improved biological potency as well as extended pharmacological activity are described herein. More specifically, the present invention relates to GLP-1 analogs (28 or 29 aa long) comprising amino acid substitutions at one or more of the following positions: 8, 20, 27, 30 and 33.

La présente invention a trait à de nouveaux analogues du GLP-1 présentant une efficacité biologique améliorée ainsi qu'une activité pharmacologique prolongée. De manière plus spécifique, la présente invention a trait à des analogues du GLP-1 (longs de 28 ou 29 acides aminés) comportant des substitutions d'acides aminés à une ou plusieurs des positions suivantes : 8, 20, 27, 30 et 33.

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