Glucagon-like peptide 1(glp-1) pharmaceutical formulations

A - Human Necessities – 61 – K

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A61K 9/16 (2006.01) A61K 38/26 (2006.01)

Patent

CA 2646400

A composition is disclosed comprising glucagon- like peptide 1 (GLP-I) particles in combination with diketopiperazine (DKP) that is stable both in vitro and in vivo. The composition has utility as a pharmaceutical formulation for treating diseases such as diabetes, cancers, and obesity but is not limited to such diseases or conditions. In particularly, the composition has utility as a pharmaceutical formulation for pulmonary delivery.

Composition à particules de peptide apparenté au glucagon 1(GLP-1) en combinaison avec la substance dikétopipérazine (DKP) stable, à la fois in vitro et in vivo, utile comme formulation pharmaceutique pour le traitement de maladies du type diabète, cancer, et obésité, sans limitation à ces cas, et en particulier utile comme formulation pharmaceutique aux fins de délivrance pulmonaire.

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