Glucagon-like peptide 1 (glp-1) receptor agonists and their...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/605 (2006.01) A61K 38/16 (2006.01) A61K 38/22 (2006.01) A61K 47/48 (2006.01) A61P 3/10 (2006.01) C07K 14/575 (2006.01) C07K 16/26 (2006.01) C07K 17/02 (2006.01) C07K 17/08 (2006.01) C12N 15/16 (2006.01) C12P 21/02 (2006.01) C07K 14/72 (2006.01)

Patent

CA 2607566

This invention provides peptides with novel modifications that provide suitable derivatization sites to improve the pharmacokinetic properties of the peptides. These GLP-1 modified peptides function in vivo as agonists of the GLP-1 receptor. The peptides of the present invention provide a new therapy for patients with decreased endogenous insulin secretion, for example, type 2 diabetics.

Peptides modifiés offrant des sites de dérivatisation appropriés qui améliorent leurs propriétés pharmacocinétiques. Ces peptides GLP-1 modifiés sont des agonistes in vivo vis-à-vis du récepteur de GLP-1. Ils offrent une solution thérapeutique pour les patients à sécrétion d'insuline endogène diminuée, par exemple dans le diabète de type 2.

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