Glucagon-like peptide and insulinotropin derivatives

Details Glucagon-like peptide and insulinotropin derivatives Glucagon-like peptide and insulinotropin derivatives

C - Chemistry, Metallurgy

07

K

C07K 14/605 (2006.01) A61K 38/22 (2006.01) A61K 38/26 (2006.01) C07K 14/575 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2138161

This invention relates to derivatives of glucagon-like peptide 1 (GLP-1), truncated GLP-1, insulinotropin and truncated in- sulinotropin which have a pl of about 4.0 or less or a pl of about 7.0 or greater. The derivatives of GLP-1, truncated GLP-1, insu- linotropin and truncated insulinotropin within the scope of this invention are particularly suited for delivery to a mammal by ion- tophoresis. This invention also relates to methods for enhancing insulin action in a mammal with said derivatives and to pharmaceutical compositions comprising said derivatives. Further still, this invention relates to new uses of certain known deriva- tives of insulinotropin and truncated insulinotropin to enhance insulin action in a mammal by iontophoretic administration of such derivatives.

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