Glucagon-like peptides and uses thereof

Details Glucagon-like peptides and uses thereof Glucagon-like peptides and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 14/605 (2006.01) A61K 38/22 (2006.01)

Patent

CA 2655923

The present invention relates to non-mammalian Glucagon-like peptides (nmGLP-1), analogs thereof, related nucleic acids, and processes production of such peptides. The nmGLP-1 peptides and analogs thereof of the invention include one or more amino acid sequence modifications. In addition, methods and compositions are disclosed to treat and prevent obesity, reducing body weight, controlling glycemia, controlling or reducing appetite, and reducing food intake.

La présente invention concerne des peptides non-mammaliens semblables au glucagon (nmGLP-1), leurs analogues, des acides nucléiques apparentés et des procédés de production de tels peptides. Les séquences d'acides aminés des peptides nmGLP-1 et de leurs analogues selon l'invention comprennent une ou plusieurs modifications. L'invention concerne également des procédés et des compositions destinés au traitement et à la prévention de l'obésité, à la réduction du poids corporel, à la régulation de la glycémie, à la régulation ou à la réduction de l'appétit et à la réduction de la consommation alimentaire.

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