Glucagon receptor antagonists

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/28 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2719761

The present invention relates to glucagon receptor polypeptide antagonists which inhibit the binding of the hormone glucagon to its receptor. More particularly, the present invention relates to high affinity glucagon receptor antibodies or Fab fragments thereof that inhibit binding of glucagon to its receptor and their use in the treatment or prevention of type 2 diabetes (NIDDM) and related disorders in mammalian species.

La présente invention porte sur des antagonistes polypeptidiques du récepteur du glucagon qui inhibent la liaison de l'hormone glucagon à son récepteur. Plus particulièrement, la présente invention porte sur des anticorps de récepteur du glucagon présentant une affinité élevée ou sur des fragments Fab de ceux-ci qui inhibent la liaison du glucagon à son récepteur et sur leur utilisation dans le traitement ou la prévention du diabète de type 2 (NIDDM) et de troubles apparentés chez les espèces de mammifères.

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