C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 235/42 (2006.01) A61K 31/197 (2006.01) A61P 3/10 (2006.01) C07C 323/60 (2006.01) C07D 213/62 (2006.01)
Patent
CA 2569459
The present invention discloses novel compounds of Formula I, or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat diabetic and other glucagon related metabolic disorders, and the like.
La présente invention concerne de nouveaux composés de formule (I), ou des sels de ceux-ci acceptables du point de vue pharmaceutique, lesquels ont une activité antagoniste ou agoniste inverse vis-à-vis des récepteurs du glucagon, ainsi que des procédés servant à préparer de tels composés. Dans un autre mode de réalisation, l'invention concerne des compositions pharmaceutiques comprenant les composés de formule (I) ainsi que des procédés d'utilisation de ceux-ci pour traiter le diabète et d'autres troubles métaboliques liés au glucagon, et similaires.
Conner Scott Eugene
Li Jianke
Zhu Guoxin
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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