Glucagon receptor antagonists, preparation and therapeutic uses

Details Glucagon receptor antagonists, preparation and therapeutic uses Glucagon receptor antagonists, preparation and therapeutic uses

C - Chemistry, Metallurgy

07

D

C07D 257/04 (2006.01) A61K 31/41 (2006.01) A61P 3/08 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2629172

The present invention discloses novel compounds of Formula (I), or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat diabetic and other glucagon related metabolic disorders, and the like.

La présente invention concerne de nouveaux composés de formule (I) ou des sels de ceux-ci, acceptables d'un point de vue pharmaceutique, qui présentent une activité d'agoniste inverse ou d'antagoniste de récepteur du glucagon, ainsi que des procédés de préparation de tels composés. Dans d'autres modes de réalisation, cette invention concerne des compositions pharmaceutiques comprenant des composés de formule (I), ainsi que des procédés d'utilisation de ceux-ci pour traiter des troubles diabétiques, d'autres troubles métaboliques liés au glucagon et des troubles similaires.

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