Glucagon receptor antagonists, preparation and therapeutic uses

Details Glucagon receptor antagonists, preparation and therapeutic uses Glucagon receptor antagonists, preparation and therapeutic uses

C - Chemistry, Metallurgy

07

C

C07C 235/42 (2006.01) A61K 31/166 (2006.01) A61K 31/4412 (2006.01) A61P 3/10 (2006.01) C07D 213/10 (2006.01)

Patent

CA 2629321

The present invention discloses novel compounds of Formula (I), or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat diabetic and other glucagon related metabolic disorders, and the like.

L'invention porte sur de nouveaux composés de la formule 1 ou des sels pharmaceutiquement acceptables de ces derniers, qui exercent une activité antagoniste ou agoniste inverse sur le récepteur du glucagon, et sur des procédés de préparation desdits composés. Dans un autre mode de réalisation, l'invention concerne des compositions pharmaceutiques renfermant les composés de la formule 1, et des procédés d'utilisation de ces derniers dans le traitement de troubles diabétiques et autres troubles métaboliques liés au glucagon, et analogues.

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