C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/16 (2006.01) C07H 21/00 (2006.01) C07K 14/72 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12Q 1/527 (2006.01) C12Q 1/66 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/74 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2142819
The present invention provides isolated DNA molecules comprising a DNA segment encoding a glucagon receptor. Also provided are DNA constructs, comprising a cast DNA segment encoding a glucagon receptor operably linked to additional DNA segments required for the expression of the first DNA segment, as well as host cells containing such DNA constructs. The present invention also provides amethod for detecting the presence of glucagon antagonists, comprising the steps of (a) exposing a com- pound in the presence of a glucagon agonist to a recombinant glucagon receptor coupled to a response pathway under conditions and for time sufficient to allow binding of the compound to the receptor and an associated response through the pathway, and (b) detecting a reduction in the stimulation of the response pathway resulting from the binding of the compound to the glucagon re- ceptor, relative to the stimulation of the response pathway by the glucagon agonist alone and therefrom determining the presence of a glucagon antagonist.
Foster Donald C.
Grant Francis J.
Jelinek Laura J.
Kindsvogel Wayne R.
Kuijper Joseph L.
Mccarthy Tetrault Llp
Novo Nordisk A/s
Zymogenetics Inc.
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