Glucocorticoid mimetics, methods of making them,...

Details Glucocorticoid mimetics, methods of making them,... Glucocorticoid mimetics, methods of making them,...

C - Chemistry, Metallurgy

07

C

C07C 311/18 (2006.01) C07C 311/17 (2006.01) C07C 321/28 (2006.01) C07D 263/00 (2006.01) C07D 295/00 (2006.01)

Patent

CA 2683653

Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, X, R7, and R8 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

La présente invention concerne des composés de formule (I) dans laquelle R1, R2, R3, R4, R5, R6, X, R7, et R8 sont tels que définis dans la description, ou un tautomère, un promédicament, un solvate, ou un sel de ceux-ci; des compositions pharmaceutiques contenant de tels composés, et des procédés de modulation de la fonction du récepteur des glucocorticoïdes et des procédés de traitement d'états morbides ou de conditions pathologiques médiés par la fonction du récepteur des glucocorticoïdes ou caractérisés par des processus inflammatoires, allergiques, ou proliférants chez un patient mettant en AEuvre ces compositions.

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