Glucocorticoid mimetics, methods of making them,...

Details Glucocorticoid mimetics, methods of making them,... Glucocorticoid mimetics, methods of making them,...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 5/44 (2006.01) A61P 5/46 (2006.01)

Patent

CA 2726449

Compounds of Formula I wherein R1, R2, X, and Y are as defined herein, or a tautomer, optical isomer, prodrug, co-crystal, or salt thereof, pharmaceutical compositions containing such compounds, and methods of modulating the glucocorti-coid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds

La présente invention concerne des composés de la formule I dans laquelle R1, R2, X et Y sont tels que définis ici, ou un tautomère, un isomère optique, un promédicament, un co-cristal ou un sel de ceux-ci ; des compositions pharmaceutiques contenant de tels composés, et des procédés de modulation de la fonction de récepteurs de glucocorticoïdes et des méthodes de traitement détats pathologiques ou daffections médiés par la fonction de récepteurs de glucocorticoïdes ou caractérisés par des procédés inflammatoires, allergiques ou prolifératifs chez un patient qui utilisent ces composés.

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