Glucocorticoid mimetics, methods of making them,...

Details Glucocorticoid mimetics, methods of making them,... Glucocorticoid mimetics, methods of making them,...

C - Chemistry, Metallurgy

07

D

C07D 249/18 (2006.01) A61K 31/416 (2006.01) A61K 31/4184 (2006.01) A61K 31/4192 (2006.01) C07D 209/10 (2006.01) C07D 231/56 (2006.01) C07D 235/12 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2610588

Compounds of Formula (IA) and (IB) wherein R1, R2, R3, A, B, C, D, and E are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

L'invention concerne des composés de formules (IA) et (IB), dans lesquelles R1, R2, R3, A, B, C, D, et E sont tels que définis dans la description, ou un tautomère, un promédicament, un solvate ou un sel de ces composés, des compositions pharmaceutiques contenant lesdits composé, ainsi que des méthodes destinées à moduler la fonction du récepteur des glucocorticoïdes et des méthodes destinées à traiter des pathologies ou des affections médiées par la fonction du récepteur des glucocorticoïdes ou caractérisées par des processus inflammatoires, allergiques ou prolifératifs chez un patient au moyen de ces composés.

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