Glucocorticoid mimetics, methods of making them,...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 209/16 (2006.01) A61K 31/4045 (2006.01) A61K 31/437 (2006.01) C07D 209/08 (2006.01) C07D 209/86 (2006.01) C07D 215/06 (2006.01) C07D 215/22 (2006.01) C07D 231/56 (2006.01) C07D 235/14 (2006.01) C07D 307/79 (2006.01) C07D 333/58 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 413/04 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2592514

Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, and R7 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

L'invention concerne des composés de formule (I), ou un tautomère, ou un promédicament, ou un solvate, ou un sel de ceux-ci. L'invention concerne des compositions pharmaceutiques contenant de tels composés et des méthodes de modulation de la fonction du récepteur glucocorticoïde, ainsi que des méthodes de traitement de troubles ou de maladies médiées par la fonction du récepteur glucocorticoïde ou caractérisées par des processus inflammatoires, allergiques ou prolifératives, chez des patients, à l'aide de ces composés. Dans la formule de l'invention, R1, R2, R3, R4, R5, R6 et R7 sont définis dans la description.

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