Glucocorticoid mimetics, methods of making them,...

Details Glucocorticoid mimetics, methods of making them,... Glucocorticoid mimetics, methods of making them,...

C - Chemistry, Metallurgy

07

D

C07D 231/56 (2006.01) A61K 31/416 (2006.01) A61K 31/437 (2006.01) A61P 5/44 (2006.01) A61P 5/46 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/06 (2006.01) C07D 409/06 (2006.01) C07D 417/06 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 498/04 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2671990

Compounds of Formula (IA), and Formula (IB), wherein R1, R2, R3, A, B, C, D, E, G, X, Y, and Z are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

L'invention concerne des composés représentés par la formule (IA), et la formule (IB), où R1, R2, R3, A, B, C, D, E, G, X, Y et Z sont tels que définis ici, ou un tautomère, promédicament, solvate ou sel de ceux-ci; des compositions pharmaceutiques contenant de tels composés, et des procédés de modulation de la fonction des récepteurs de glucocorticoïde et des procédés de traitement d'états maladifs ou d'affections véhiculés par la fonction des récepteurs de glucocorticoïde ou caractérisés par des processus inflammatoires, allergiques ou prolifératifs chez un patient utilisant ces composés.

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