Glucocorticoid receptor antagonists for the treatment of...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/567 (2006.01) A61K 9/20 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2328411

This invention generally pertains to the field of psychiatry. In particular, this invention pertains to the discovery that agents which inhibit the binding of cortisol to its receptors can be used in methods for treating dementia. Mifepristone, a potent glucocorticoid receptor antagonist, can be used in these methods. The invention also provides a kit for treating dementia in a human including a glucocorticoid receptor antagonist and instructional material teaching the indications, dosage and schedule of administration of the glucocorticoid receptor antagonist.

L'invention, qui relève du domaine de la psychiatrie, concerne plus précisément la découverte selon laquelle il est possible, pour traiter la démence, d'utiliser des agents qui inhibent la fixation du cortisol à son récepteur. Il est possible d'employer, dans le cadre de ces méthodes, du mifépristone, puissant antagoniste du récepteur de glucocorticoïde. Cette invention porte également sur un nécessaire de traitement de la démence humaine comprenant un antagoniste du récepteur de glucocorticoïde et du matériel didactique donnant des indications, le dosage et l'échéancier d'administration de cet antagoniste du récepteur de glucocorticoïde.

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