Glucocorticoid receptor modulators

Details Glucocorticoid receptor modulators Glucocorticoid receptor modulators

C - Chemistry, Metallurgy

07

D

C07D 413/04 (2006.01) A61K 31/4245 (2006.01) A61K 31/5377 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) C07D 271/06 (2006.01) C07D 271/10 (2006.01) C07D 413/06 (2006.01)

Patent

CA 2360313

The present invention provides non-steroidal compounds of Formula I, including prodrugs and pharmaceutically acceptable salts thereof, which are selective modulators (e.g., agonists, partial agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions containing these compounds and methods for using these compounds to treat animals requiring glucocorticoid receptor agonist or antagonist therapy. Glucocorticoid receptor modulators are useful to treat diseases, such as obesity, diabetes, inflammation and others as described below. The present invention also provides processes for preparing these compounds.

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