Glucokinase activator

Details Glucokinase activator Glucokinase activator

C - Chemistry, Metallurgy

07

D

C07D 213/80 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/421 (2006.01) A61K 31/425 (2006.01) A61K 31/426 (2006.01) A61K 31/428 (2006.01) A61K 31/433 (2006.01) A61K 31/437 (2006.01) A61K 31/4375 (2006.01) A61K 31/44 (2006.01) A61K 31/4402 (2006.01) A61K 31/4406 (2006.01) A61K 31/4409 (2006.01) A61K 31/4439 (2006.01) A61K 31/455 (2006.01) A61K 31/47 (2006.01) A61K 31/472 (2006.01) A61K 31/4965 (2006.01) A61K 31/50 (2006.01) A61K 31/505 (2006.01) A61K 31/519 (2006.01) A61P 3/04 (2006.01) A61P 3

Patent

CA 2672088

Disclosed is a compound represented by the formula (1) or a pharmaceutically acceptable salt thereof, wherein a carbon atom having an asterisk has an R-configuration; R1 and R2 independently represent a hydrogen atom, a halogen atom, an amino group, a hydroxy group, a hydroxyamino group, a nitro group, a cyano group, a sulfamoyl group, a C1-C6 alkyl group, a C1-C6 alkoxy group, a C1-C6 alkylsulfanyl group, a C1-C6 alkylsulfinyl group or a C1-C6 alkylsulfonyl group; and A represents a heteroaryl group which may have a substituent.

L'invention concerne un composé représenté par la formule (1) ou un sel pharmaceutiquement acceptable de celui-ci, dans laquelle un atome de carbone ayant un astérisque a une configuration R; R1 et R2 représentent indépendamment un atome d'hydrogène, un atome d'halogène, un groupe amino, un groupe hydroxy, un groupe hydroxy-amino, un groupe nitro, un groupe cyano, un groupe sulfamoyle, un groupe alkyle en C1-C6, un groupe alcoxy en C1-C6, un groupe alkylsulfanyle en C1-C6, un groupe alkylsulfinyle en C1-C6 ou un groupe alkylsulfonyle en C1-C6; et A représente un groupe hétéroaryle qui peut avoir un substituant.

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