Glucokinase activators

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 417/12 (2006.01) A61K 31/4439 (2006.01) A61P 3/10 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2628274

Provided are compounds of Formula I wherein R1, R2, Y, Z and G are as defined herein, that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes mellitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase.

La présente invention concerne des composés de Formule I où R1, R2, Y, Z et G sont tels que définis dans l'invention, et pouvant être employés dans le traitement prophylactique et/ou thérapeutique de maladies faisant intervenir une activité glucokinase déficiente, comme le diabète sucré. La présente invention porte également sur des méthodes de traitement prophylactique ou thérapeutique de maladies et de troubles caractérisés par une sous-activité des glucokinases, ou pouvant être traités par l'activation des glucokinases.

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