Glucokinase activators

Details Glucokinase activators Glucokinase activators

C - Chemistry, Metallurgy

07

D

C07D 277/46 (2006.01) A61K 31/17 (2006.01) A61K 31/4164 (2006.01) A61K 31/4168 (2006.01) A61K 31/42 (2006.01) A61K 31/421 (2006.01) A61K 31/426 (2006.01) A61K 31/433 (2006.01) A61K 31/4402 (2006.01) A61K 31/4965 (2006.01) A61K 31/501 (2006.01) A61K 31/505 (2006.01) A61K 31/53 (2006.01) A61P 3/10 (2006.01) C07C 275/50 (2006.01) C07C 317/44 (2006.01) C07C 323/62 (2006.01) C07D 213/75 (2006.01) C07D 213/80 (2006.01) C07D 213/82 (2006.01) C07D 213/85 (2006.01) C07D 233/88 (2006.01) C07D 237/20 (2006.01) C07D 23

Patent

CA 2368347

The present invention relates to compounds of formula (I) wherein R1, R2, R3 and R4 are as defined in claim 1 and pharmaceutically acceptable salts thereof. The compounds are glucokinase activators which increase insulin secretion in the treatment of type II diabetes.

L'invention concerne des composés représentés par la formule (I) dans laquelle R<1>, R<2>, R<3> et R<4> sont définis dans la revendication 1. L'invention concerne également des sels pharmaceutiquement acceptables de ces composés. Ces composés sont des activateurs de glucokinase qui augmentent la sécrétion d'insuline pour le traitement du diabète du type II.

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