Glucopyranosides conjugates of...

Details Glucopyranosides conjugates of... Glucopyranosides conjugates of...

C - Chemistry, Metallurgy

07

H

C07H 17/02 (2006.01) A61K 31/7056 (2006.01) A61P 5/30 (2006.01) A61P 5/32 (2006.01) C07H 15/26 (2006.01)

Patent

CA 2382683

This invention provides tissue selective estrogens of formula (I) having structure (I) wherein: R1 and R2 are independently, hydrogen, alkyl chain of 1- 6 carbon atoms, benzyl, acyl of 2-7 carbon atoms, benzoyl, (1) or (2); X is hydrogen, alkyl of 1-6 carbon atoms, CN, halogen, trifuoromethyl, or thioalkyl of 1-6 carbon atoms; n = 1-3; with the proviso that at least one of R1 or R2 is (1) or (2); or a pharmaceutically acceptable salt thereof.

L'invention concerne des oestrogènes sélectifs de tissu de formule (I) possédant la structure (I) dans laquelle R¿1? et R¿2? sont indépendamment, hydrogène, cycle alkyle de 1 à 6 atomes de carbone, benzyle, acyle de 2 à 7 atomes de carbone, benzoyle, (1) ou (2); X est hydrogène, alkyle de 1 à 6 atomes de carbone, CN, halogène, trifluorométhyle, ou thioalkyle de 1 à 6 atomes de carbone; n = 1-3; à condition qu'au moins un R¿1? ou R¿2? soit (1) ou (2); ou encore un sel pharmaceutiquement acceptable de ceux-ci.

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